April 2013
Efficacy of Subgingivally Delivered Satranidazole in the Treatment of Type 2 Diabetes Subjects with Chronic Periodontitis: A Randomized Controlled Clinical Trial
Abstract
Background: The present clinical trial was designed to investigate the effectiveness of subgingivally delivered satranidazole (SZ) gel as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis. Methods: Sixty-four subjects with probing depth (PD) ≥ 5 mm and who were diagnosed with type 2 diabetes were selected. Thirty-two subjects each were randomly assigned to SRP + placebo (Group 1) and SRP + SZ (Group 2). The clinical outcomes evaluated were plaque index (PI), gingival index (GI), clinical attachment level (CAL) and PD at baseline, 1 month, 3-months and 6 months. Results: At 6 months, Group 2 had greater mean reduction (4.73 mm) in PD as compared to Group 1 (2.09 mm; p < 0.05) and also a greater mean CAL gain (3.92 mm versus 1.64 mm; p < 0.05). Conclusion: The use of 3% SZ gel, when used as an adjunct to non-surgical periodontal therapy in subjects with periodontitis, achieves significantly better clinical results than initial periodontal treatment alone.
Other articles in this issue
| Article | |
| The Effect of In Vitro Fertilization on Gingival Inflammation According to Women's Periodontal Status: Clinical Data Anthodesmi Pavlatou, Alexandra Tsami, Nicolaos Vlahos, Themis Mantzavinos and Ioannis Vrotsos | Download |
| A Randomized Controlled Clinical Trial on the Clinical and Microbiological Efficacy of Systemic Satranidazole in the Treatment of Chronic Periodontitis A. R. Pradeep, Priyanka N, Nitish Kalra and Savitha B Naik | Download |
| IAP 14th International Biennial Congress | Download |
| Subgingival Root Brushing in Deep Human Periodontal Pockets Lawrence R. Page and Thomas E. Rams | Download |
| IAP World Conclave | Download |
