Our understanding of the etiology and pathogenesis of periodontitis has dramatically improved over the last three decades. The primary etiological role of dental biofilm has been well established; a number of periodontal pathogens have been identified and characterized; and wide arrays of virulence factors and pathogenic mechanisms have been determined. It has also become clear that tissue damage in periodontitis is mostly the result of destructive host immune responses rather than a direct bacterial assault, and many of these have been elucidated. To our disappointment, however, this seems to have little clinical significance so far as periodontitis continues to be treated as a non-specific infection, and to impose a high level of morbidity and an economic burden to societies (Loesche and Grossman, 2001).
|A Metaproteomic Approach to the Study of Pathogenesis of Periodontitis - Current Opinions in Periodontology Nezar Noor Al-hebshi||Download|
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|Association of Antimicrobial and Clinical Efficacy: Periodontitis Therapy with Minocycline Microspheres Paul S. Bland, J. Max Goodson, John C. Gunsolley, Sara G. Grossi, Joan Otomo-Corgel, Frances Doherty and Judith L. Comiskey||Download|
|Clinical and Microbiological Effects of Adjunctive, Locally Delivered Chlorhexidine on Patients with Chronic Periodontitis Sakellari Dimitra, Loannidis Loannis, Antoniadou Malama, Slini Theodora and Konstantinidis Antonis||Download|
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